Formulation and Evaluation of Niosomal Gel of Antifungal Luliconazole

Niosomes have potential applications in topical drug delivery system. play an increasingly important role as they can reduce toxicity and modify pharmacokinetic bio-availability. Topically applied niosomes increase the residence time of drugs stratum corneum epidermis, while reducing systemic absorption drug. It act containing reservoirs modification vesicular compositions or surface properties adjust release rate affinity for target site. Luliconazole is a prescription candidate treatment fungal infections. However, it has water solubility skin permeability limitations. To overcome these limitations, niosomal gel luliconazole was formulated using Span 60, cholesterol chloroform to improve its bioavailability toxicity. were analyzed by transmission electron microscopy (TEM) Fourier transform infrared spectroscopy (FTIR) morphological spectral studies respectively. The formulations had ideal nanometric vesicle sizes, encapsulation efficiency (88.891% ± 0.0364%), Zeta (-40.1 mV), storage instability not observed. sustained-release profile observed up 24 h. highest R2 value 0.913; Higuchi model considered best fit formulations. Based on results, be concluded that may enhance activity against Candida albicans.
 Keywords: Luliconazole, Niosomes, Transdermal delivery, Antifungal drugs, albicans